UN Secretary-General Ban Ki-moon has demanded a cease-fire in Syria before peace talks between the government and opposition begin in Geneva next month.
The comment comes as Ban addressed a year-end press conference at the UN headquarters in New York City.
He urges all countries with any power and influence on the parties to demand a stop to the fighting before the Geneva conference.
"2013 was the year in which the Syrian conflict deteriorated beyond all imagination. The people of Syria cannot afford another year, another month, even another day of brutality and destruction. We must have cessation of hostilities before we begin political dialogue on Syria in Geneva."
The UN secretary-general says he will soon issue invitations to the Geneva conference.
Meanwhile, he also calls for support to address the dire humanitarian situation in Syria as the UN launches its biggest ever aid appeal.
"The 2014 appeal for Syria launched today in Geneva is the biggest in the history of the United Nations: $6.5 billion to meet needs inside Syria and to help the more than 2 million people who have fled the country. I call for generous support, including at the pledging conference I will convene on January 15th in Kuwait."
Earlier, the UN announced they need almost 13 billion US dollar to help people in 17 crisis-affected countries.
Half of the overall funding is needed for Syria.
The UN says more than 100-thousand people have been killed and over 6 million others have been internally displaced since the conflict broke out in March 2011.
More than two million Syrians have fled to neighboring countries, including Jordan, Lebanon and Turkey.